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On the part of the cardiovascular system, there is a decrease in heart rate and an increase in blood pressure. Ketorolac and bronchopneumonia are often detected. Often determined by an increase in the liver and spleen, as well as polyadenitis.
Urinary excretion in patients is usually reduced. Depending on the severity of toradol and hemorrhagic syndromes, obliterated, mild, moderate and severe forms of the disease are distinguished. The latter are characterized by massive hemorrhagic syndrome, encephalitis, coma, renal failure and early death of patients (on the 3-5th day of illness). With a general blood test, there is a decrease in the level of leukocytes, an increase in the number of lymphocytes, an almost complete absence of neutrophils, and a decrease in the level of platelets. A decrease in the level of prothrombin, fibrinogen and other blood coagulation factors is naturally detected. Often determined by the presence in the urine of albumin, blood, cylinders. Mortality ranges from 6 to 20%.
The diagnosis of the disease is made on the basis of anamnesis data, clinical and laboratory studies. Specific diagnosis consists in the isolation of the virus in the first 3-12 days of the disease and antibodies that neutralize the virus at the end of the 3rd week of the disease.
Currently, there is no specific therapy. Treatment of Ketorolac is symptomatic aimed at eliminating shock and detoxification. There is evidence of a positive effect of the administration of convalescent plasma to patients at the height of the disease. With such manipulations, mortality decreases from 16% to 1%. In an experiment with primates showing the effectiveness of ribavirin.
Specific prophylaxis has not been established. Prevention of the disease is achieved by non-specific methods. The basis of preventive measures is deratization, dezinesktization, ensuring compliance with hygienic requirements for food and inhaled air.
The Candid #1 AHF vaccine was developed in 1985 by Argentinean virologist Dr. Julio Barrera-Oro. The vaccine was manufactured at the Salk Institute in the USA and has been available in Argentina since 1990.
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Candid#1 has been applied to adults at high risk of toradol. Effective at 95.5%. On August 29, 2006, the Maiztegui Institute received a certificate for vaccine production in Argentina. The vaccination plan has not yet been laid out, but the 2007 budget allows for 390,000 doses to be made, in Argentina it costs 8 pesos each (about $2.6 or €2). The institute has the capacity to produce in one year 5 million doses needed to vaccinate the entire population of endemic areas.